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Updated: Oct 5, 2025

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

Toward Multiplexed Optogenetic Circuits.

Ari Dwijayanti¹, Congqiang Zhang², Chueh Loo Poh³

¹CNRS@CREATE, Singapore, Singapore.

Frontiers in Bioengineering and Biotechnology

|January 24, 2022

Summary

This summary is machine-generated.

Light-sensitive proteins enable precise control of cellular functions. Multiplexed optogenetic circuits combine multiple photoreceptors for advanced dynamic regulation in biotechnology.

Keywords:

biotechnological applications engineered photoreceptor modules light-sensitive proteins metabolic engineering multiplexed regulation optogenetic circuits

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Last Updated: Oct 5, 2025

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

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Published on: September 1, 2022

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

Area of Science:

Biotechnology
Synthetic Biology
Optogenetics

Background:

Light is a ubiquitous tool for controlling cellular behaviors.
Light-sensitive proteins are crucial for adaptive biological regulations.
Optogenetics utilizes engineered light-sensitive proteins for synthetic genetic circuits.

Purpose of the Study:

To review recent advancements in multiplexed optogenetic circuits.
To discuss challenges and future directions in optogenetic tool development.
To highlight the potential for dynamic regulation in biotechnological applications.

Main Methods:

Exploration and engineering of natural light-sensitive proteins.
Design of complex systems with multiple wavelength-specific photoreceptors.
Integration of optogenetic circuits in natural and engineered systems.

Main Results:

Expansion of optogenetic toolboxes with tailored performances.
Development of systems for simultaneous coordination of cellular responses.
Demonstration of dynamic regulation capabilities in single cells.

Conclusions:

Multiplexed optogenetic circuits offer significant potential for biotechnological innovation.
Further engineering of light-sensitive proteins is key to advancing optogenetics.
Coordinated cellular responses via optogenetics pave the way for dynamic regulation breakthroughs.