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3D-bioprinted microenvironments for sweat gland regeneration
Wei Song1, Bin Yao1, Dongzhen Zhu1
1Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, 28 Fu Xing Road, Beijing 100853, P. R. China.
Burns & Trauma
|January 24, 2022
Summary
3D bioprinting creates artificial microenvironments to regenerate sweat glands (SGs). This review explores advances in 3D bioprinted environments for functional SG repair, focusing on regulatory mechanisms for improved stem cell therapy.
Area of Science:
- Regenerative Medicine
- Biotechnology
- Tissue Engineering
Background:
- Sweat glands (SGs) are crucial for thermoregulation but possess limited regenerative capacity after injury.
- Stem cell-based therapies are being investigated for SG repair strategies.
- 3D bioprinting offers novel approaches to create functional in vitro microenvironments.
Purpose of the Study:
- To review recent advancements in 3D bioprinting for creating native-like microenvironments.
- To highlight the application of 3D bioprinting in functional sweat gland regeneration.
- To discuss regulatory mechanisms influencing regeneration within 3D bioprinted constructs.
Main Methods:
- Review of current literature on 3D bioprinting and stem cell-based regeneration.
- Analysis of studies focusing on 3D bioprinted microenvironments for sweat gland repair.
- Identification and discussion of regulatory factors (biochemical, structural, mechanical, cellular, vascular).
Main Results:
- 3D bioprinting enables the creation of sophisticated in vitro microenvironments that mimic native tissue.
- Significant progress has been made in utilizing these engineered environments for functional SG regeneration.
- Key regulatory mechanisms, including biochemical cues, physical properties, cell-cell interactions, and vascularization, are crucial for successful regeneration.
Conclusions:
- 3D bioprinting is a promising technology for developing effective stem cell-based therapies for sweat gland regeneration.
- Understanding and manipulating the complex regulatory cues within 3D bioprinted microenvironments is essential for optimizing regenerative outcomes.
- Future research should focus on integrating these regulatory factors to enhance the functional recovery of damaged sweat glands.
