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Transcatheter Mitral Valve-in-Valve Implantation in Pediatric Patients

Mohamed Al Nasef1, Atif Alsahari1, Ahmed Eltayeb1

  • 1Pediatric Cardiology Department, Prince Sultan Cardiac Centre, Riyadh, Kingdom of Saudi Arabia.

CJC Open
|January 24, 2022
PubMed

Insights

Transcatheter mitral valve-in-valve implantation is a safe and effective treatment for children with malfunctioning bioprosthetic mitral valves. This procedure offers a promising alternative to surgery, improving patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Pediatric Cardiology
  • Interventional Cardiology

Background:

  • Transcatheter mitral valve-in-valve (MViV) implantation using the Edwards Sapien 3 valve is established in adults.
  • Limited data exists on MViV in the pediatric population.

Purpose of the Study:

  • To evaluate the safety and efficacy of transcatheter MViV implantation in pediatric patients with dysfunctional mitral valve bioprostheses.
  • To assess early and midterm outcomes in this cohort.

Main Methods:

  • Retrospective review of 4 symptomatic pediatric patients undergoing transcatheter MViV implantation.
  • Procedure performed for dysfunctional bioprosthetic mitral valves (MV) due to stenosis or regurgitation.

Main Results:

  • Successful implantation in all 4 patients (mean age 11.4 years).
  • Significant reduction in transmitral mean gradient (19.75 to 1 mm Hg).
  • Improved New York Heart Association functional class from IV to I; mean hospital stay 4 days.

Conclusions:

  • Transcatheter MViV implantation is a safe and effective option for pediatric patients with dysfunctional bioprosthetic MVs.
  • Offers a viable alternative for high-risk surgical candidates.
  • Long-term, multicenter studies are recommended to further validate outcomes.
Abstract

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