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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

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Published on: May 5, 2014

Highly adaptive Phenuiviridae with biomedical importance in multiple fields.

Ming-Hui Sun¹, Yu-Fei Ji¹, Guo-Hui Li¹

¹School of Life Science and Engineering, Foshan University, Guangdong, China.

Journal of Medical Virology

|January 24, 2022

Summary

Phenuiviridae viruses infect animals, plants, and fungi, posing significant global health and agricultural risks. This review details their biology, control, and impact, aiding researchers in risk analysis.

Keywords:

Phenuiviridae arbovirus evolution genome pathogenesis

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Area of Science:

Virology
Molecular Biology
Epidemiology

Background:

The virus family Phenuiviridae, within the order Bunyavirales, is notable for infecting hosts across three kingdoms: animals, plants, and fungi.
Many phenuiviruses are arboviruses, necessitating replication in two distinct hosts, such as insects and vertebrates or plants.
Several species, including Dabie bandavirus, Rift Valley fever phlebovirus, and Rice stripe tenuivirus, exhibit high pathogenicity, causing substantial burdens on human health, livestock, and agriculture.

Purpose of the Study:

To provide a comprehensive overview of the Phenuiviridae family, synthesizing recent advances in research.
To highlight the biomedical significance, distribution, morphology, genomics, taxonomy, evolution, replication, transmission, pathogenesis, and control strategies for phenuiviruses.
To assist researchers in understanding this adaptive virus family and conducting relevant risk analyses.

Main Methods:

This review synthesizes existing research and recent findings on Phenuiviridae.
It integrates data on viral characteristics, host interactions, and epidemiological impact.
Taxonomic and evolutionary analyses are discussed based on current scientific literature.

Main Results:

Phenuiviridae represents a rare virus family with a broad host range across animals, plants, and fungi.
Pathogenic species within this family pose significant threats to global health and agriculture.
Recent advancements have expanded the understanding of Phenuiviridae taxonomy and biology.

Conclusions:

Phenuiviridae are highly adaptive viruses with significant global impact, necessitating continued research.
A comprehensive understanding of their biology and transmission is crucial for effective risk management.
This review provides a valuable resource for researchers studying phenuiviruses across various disciplines.