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Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

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Low grade gliomas.

Jeremy C Ganz¹

¹Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

Progress in Brain Research

|January 25, 2022

Summary

This summary is machine-generated.

Low grade gliomas, including pilocytic astrocytoma (grade I) and diffuse astrocytomas/oligodendrogliomas (grade II), present unique treatment challenges. Gamma Knife Neurosurgery (GKNS) shows promise for specific, smaller, or treatment-resistant tumors.

Keywords:

Diffuse astrocytoma Oligodendroglioma Pilocytic astrocytoma

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Area of Science:

Neuro-oncology
Neurosurgery
Radiation Oncology

Background:

Low-grade gliomas encompass pilocytic astrocytoma (WHO grade I) and diffuse astrocytomas/oligodendrogliomas (WHO grade II).
Pilocytic astrocytomas are well-defined with characteristic histology, often cystic.
Grade II tumors, including oligodendrogliomas and diffuse astrocytomas, require specific treatment strategies.

Purpose of the Study:

To review the role and efficacy of Gamma Knife Neurosurgery (GKNS) in managing low-grade gliomas.
To highlight the differential treatment response in adult versus pediatric low-grade gliomas.
To assess GKNS as an ancillary treatment for specific low-grade glioma subtypes.

Main Methods:

Review of literature on low-grade glioma treatment modalities.
Analysis of GKNS application in surgically inaccessible or treatment-resistant gliomas since 1994.
Comparison of treatment outcomes in adult and pediatric populations.

Main Results:

Pilocytic astrocytoma is the sole grade I glioma.
Adult low-grade gliomas demonstrate greater treatment resistance compared to pediatric cases.
GKNS is beneficial for smaller, previously untreated tumors and may serve as an ancillary treatment for smaller grade II astrocytomas.

Conclusions:

Low-grade gliomas necessitate tailored treatment approaches based on grade and histology.
GKNS offers a valuable option for specific low-grade glioma cases, particularly smaller or refractory tumors.
Further research into GKNS efficacy in adult low-grade gliomas is warranted given observed resistance.