Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

2.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.9K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K
Overview of the Vascular System01:20

Overview of the Vascular System

3.1K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

151
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
151
Lipid Catabolism01:25

Lipid Catabolism

224
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
224
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

106.9K
Overview
106.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CES1 deficiency is associated with metabolic reprograming and endothelial dysfunction in pulmonary arterial hypertension.

American journal of respiratory and critical care medicine·2026
Same author

NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis.

Cell metabolism·2026
Same author

Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair.

Nature communications·2026
Same author

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell renal cell carcinoma.

JCI insight·2025
Same author

Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs.

Journal of visualized experiments : JoVE·2025
Same author

Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis.

JACC. Advances·2025

Related Experiment Video

Updated: Oct 5, 2025

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.8K

Endothelial Lipid Metabolism.

Boa Kim1, Zolt Arany1

  • 1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Cold Spring Harbor Perspectives in Medicine
|January 25, 2022
PubMed
Summary
This summary is machine-generated.

This review highlights the crucial role of lipids in endothelial cell metabolism. It examines how these cells utilize lipids for nutrient transport and during blood vessel formation (angiogenesis).

More Related Videos

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

3.0K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.0K

Related Experiment Videos

Last Updated: Oct 5, 2025

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly
06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.8K
Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

3.0K
On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.0K

Area of Science:

  • Endothelial cell biology
  • Metabolic pathways
  • Lipid metabolism

Background:

  • Endothelial cells (ECs) are vital for organismal metabolism and nutrient transport.
  • While glucose metabolism in ECs is well-studied, lipid roles are less understood.
  • Lipids are critical for EC functions, including angiogenesis.

Purpose of the Study:

  • To review recent advancements in understanding lipid metabolism in endothelial cells.
  • To focus on lipid uptake and transport in quiescent endothelium.
  • To explore the utilization of lipid pathways during angiogenesis.

Main Methods:

  • Literature review of recent developments.
  • Analysis of lipid transport mechanisms in ECs.
  • Examination of lipid pathway involvement in angiogenesis.

Main Results:

  • Lipid transport and utilization by ECs are essential for their functions.
  • Lipid pathways play a significant role in quiescent endothelium.
  • Angiogenesis heavily relies on specific endothelial lipid metabolic pathways.

Conclusions:

  • Lipids are fundamental to endothelial cell metabolism and function.
  • Further research into endothelial lipid metabolism is warranted.
  • Understanding lipid roles can inform therapeutic strategies for vascular diseases.