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Transcription shifts in gut bacteria shared between mothers and their infants

Tommi Vatanen1,2, O Sakwinska3, B Wilson4

  • 1Liggins Institute, The University of Auckland, Private Bag 102904, Auckland, New Zealand. t.vatanen@auckland.ac.nz.

Scientific Reports
|January 25, 2022
PubMed

The infant gut microbiome contains a portion of bacteria that originate from the maternal gut. In the infant gut these bacteria encounter a new metabolic environment that differs from the adult gut, consequently requiring adjustments in their activities. We used pilot community RNA sequencing data (metatranscriptomes) from ten mother-infant dyads participating in the NiPPeR Study to characterize bacterial gene expression shifts following mother-to-infant transmission. Maternally-derived bacterial strains exhibited large scale gene expression shifts following the transmission to the infant gut, with 12,564 activated and 14,844 deactivated gene families. The implicated genes were most numerous and the magnitude shifts greatest in Bacteroides spp. This pilot study demonstrates environment-dependent, strain-specific shifts in gut bacteria function and underscores the importance of metatranscriptomic analysis in microbiome studies.

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