Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.3K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.3K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

669
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
669
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

818
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
818
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

75
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
75
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

693
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
693
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

70
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Habitual creatine intake is associated with greater lean body mass and handgrip strength in the U.S. general population.

Nutrition and health·2026
Same author

The game of chess: Future directions for sports nutrition and supplementation.

Nutrition and health·2026
Same author

Prior-night sleep duration and the relationship to quality of life and educational context in Norwegian pre-adolescents.

BMC pediatrics·2026
Same author

Beyond plasma signatures: reframing bioenergetic disruption in long COVID as a neurological disorder.

Journal of translational medicine·2026
Same author

Association Between Sub-National Regional Socioeconomic Status and Childhood Obesity in Five South-East European Countries: The WHO European Childhood Obesity Surveillance Initiative-COSI (2019).

Children (Basel, Switzerland)·2026
Same author

Establishing Dietary Reference Intakes for Creatine in Adults.

Nutrition reviews·2026

Related Experiment Video

Updated: Oct 5, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.3K

Nitric Oxide: The Missing Factor in COVID-19 Severity?

Alexandros Nikolaidis1, Ron Kramer2, Sergej Ostojic3

  • 1NKG Pharmaceuticals, Signal Hill, CA 90755, USA.

Medical Sciences (Basel, Switzerland)
|January 25, 2022
PubMed
Summary
This summary is machine-generated.

Researchers propose that nitric oxide depletion may cause severe COVID-19 symptoms and comorbidities. A nutritional intervention using nitrate, a nitric oxide precursor, is being investigated to address this link.

Keywords:
COVID-19NOSARS-CoV-2comorbiditiesetiologynitric oxide

More Related Videos

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.4K
Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

2.1K

Related Experiment Videos

Last Updated: Oct 5, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
05:46

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

5.3K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.4K
Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins
10:07

Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins

Published on: March 17, 2023

2.1K

Area of Science:

  • Cardiovascular research
  • Infectious diseases
  • Nutritional science

Background:

  • Coronavirus disease 2019 (COVID-19) presents with diverse symptoms and varying severity, often exacerbated by comorbidities.
  • The precise mechanisms linking COVID-19 severity, comorbidities, and atypical respiratory symptoms remain unclear.
  • Nitric oxide (NO) plays a crucial role in vascular and respiratory health.

Purpose of the Study:

  • To investigate the hypothesis that nitric oxide depletion is associated with negative clinical outcomes in COVID-19 patients.
  • To explore the potential role of nitric oxide in COVID-19 related comorbidities and symptoms.
  • To evaluate a nutritional intervention based on nitrate, a nitric oxide precursor.

Main Methods:

  • The study focuses on a hypothesis-driven approach linking nitric oxide levels to COVID-19 outcomes.
  • A nutritional formulation intervention utilizing nitrate, a precursor to nitric oxide, was developed.
  • The research aims to correlate nitric oxide depletion with observed patient symptoms and comorbidities.

Main Results:

  • The study hypothesizes a direct link between nitric oxide depletion and both COVID-19 symptoms and comorbidities.
  • Negative clinical outcomes in COVID-19 patients are suggested to be associated with low nitric oxide levels.
  • The developed nutritional formulation targets nitric oxide restoration.

Conclusions:

  • Nitric oxide depletion is proposed as a unifying factor for COVID-19 severity and associated comorbidities.
  • Restoring nitric oxide levels through nutritional intervention may mitigate negative clinical outcomes.
  • Further research is warranted to validate the role of nitric oxide in COVID-19 pathogenesis and treatment.