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UALCAN: An update to the integrated cancer data analysis platform
Darshan Shimoga Chandrashekar1, Santhosh Kumar Karthikeyan1, Praveen Kumar Korla1
1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Neoplasia (New York, N.Y.)
|January 25, 2022
Summary
UALCAN is a web portal that analyzes cancer genomic, transcriptomic, and proteomic data. It provides researchers with tools to explore gene expression, protein levels, and patient survival across various cancers.
Area of Science:
- Cancer research
- Bioinformatics
- Genomics and proteomics
Background:
- Cancer profiling generates vast datasets requiring advanced analysis tools.
- Existing tools may lack comprehensive integration of multi-omics data and survival analysis.
Purpose of the Study:
- To present UALCAN, a web portal for exploring, analyzing, and visualizing cancer multi-omics data.
- To update and expand UALCAN with new data types and features based on user feedback.
Main Methods:
- Integrated The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) datasets.
- Developed a web portal for user-friendly access to pre-computed analyses.
- Incorporated data on gene expression, microRNAs, long non-coding RNAs, DNA methylation, and proteomics.
Main Results:
- UALCAN provides access to gene/protein expression, methylation status, and survival analyses across 33 cancer types.
- Expanded resource now includes miRNA, lncRNA, DNA methylation, and CPTAC proteomics data.
- New visualization tools aid in hypothesis generation and data integration.
Conclusions:
- UALCAN serves as a valuable, widely-used resource for the cancer research community.
- The updated UALCAN facilitates deeper understanding and discovery in cancer multi-omics research.
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