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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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PSC associated inflammatory bowel disease: a distinct entity.

Alireza Beheshti-Maal1,2, Atena Tamimi2, Shahrokh Iravani3

  • 1Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Expert Review of Gastroenterology & Hepatology
|January 26, 2022
PubMed
Summary

Primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD) presents unique clinical, genetic, and microbiota features. Recognizing PSC-IBD as distinct necessitates new diagnostic guidelines and therapies.

Keywords:
PSC associated IBDPSC-IBDPrimary sclerosing cholangitisinflammatory bowel diseases

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Immunology

Background:

  • Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease.
  • PSC often leads to end-stage liver disease and is frequently associated with inflammatory bowel diseases (IBDs).
  • PSC-IBD may represent a distinct entity separate from classic Crohn's disease and ulcerative colitis.

Purpose of the Study:

  • To review the unique clinical, genetic, and microbiota characteristics of PSC-IBD.
  • To explore the potential of PSC-IBD as a distinct disease entity.
  • To highlight the need for tailored diagnostic and therapeutic strategies for PSC-IBD.

Main Methods:

  • Literature review focusing on clinical presentations of PSC-IBD.
  • Analysis of genetic factors associated with PSC-IBD.
  • Examination of microbiota profiles in PSC-IBD patients.

Main Results:

  • PSC-IBD exhibits specific genetic, clinical, and microbial signatures.
  • These unique characteristics support the classification of PSC-IBD as a distinct entity.
  • Current understanding of PSC-IBD is evolving beyond traditional IBD classifications.

Conclusions:

  • The distinct features of PSC-IBD suggest it is a separate disease entity.
  • Formal recognition of PSC-IBD requires the development of new clinical guidelines.
  • Novel therapeutic approaches are needed to address the specificities of PSC-IBD.