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Updated: Oct 5, 2025
10:15
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
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Genetics in aphasia recovery
Sigfus Kristinsson1, Julius Fridriksson1
1Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC, United States.
Handbook of Clinical Neurology
|January 26, 2022
Summary
Genetic factors may explain variability in aphasia recovery. Further research into stroke genetics and brain-derived neurotrophic factor (BDNF) polymorphism is crucial for improving predictive models of language function recovery.
Area of Science:
- Neuroscience
- Genetics
- Speech-Language Pathology
Background:
- Aphasia recovery models lack precision.
- Genetic factors may influence language recovery after stroke.
- Previous studies on BDNF val66met polymorphism yielded mixed results.
Purpose of the Study:
- To review evidence for a genetic basis in aphasia recovery.
- To discuss implications of recent genetic findings for language function.
- To propose future research directions in genetics and recovery.
Main Methods:
- Literature review of genetic studies in aphasia recovery.
- Analysis of candidate-gene and genome-wide association studies.
- Discussion of direct and indirect genetic evidence.
Main Results:
- Genetic data may account for unexplained variability in aphasia recovery.
- Advances in stroke genetics offer insights into language recovery.
- The role of BDNF val66met polymorphism requires further investigation.
Conclusions:
- Genetics plays a significant role in aphasia recovery.
- Future research should integrate genetic data into recovery models.
- Understanding genetics can lead to personalized aphasia treatments.
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