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Spontaneous Murine Model of Anaplastic Thyroid Cancer

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Published on: February 3, 2023

Functioning metastasis from adrenocortical carcinoma.

Clara Cunha¹, Sara Donato², Tiago Silva²

¹Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal cicunha@chlo.min-saude.pt.

BMJ Case Reports

|January 26, 2022

Summary

This summary is machine-generated.

Recurrence of Cushing's syndrome from adrenocortical carcinoma (ACC) metastasis post-adrenalectomy is rare. This case highlights rapid, widespread metastasis despite initial R0 resection and symptom improvement.

Keywords:

adrenal disorders endocrinology

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Area of Science:

Endocrinology
Oncology
Nuclear Medicine

Background:

Adrenocortical carcinoma (ACC) is a rare malignancy with significant morbidity.
Cushing's syndrome can be caused by functional adrenal tumors.
Metastasis from ACC typically occurs late in the disease course.

Observation:

A 56-year-old woman presented with Cushing's syndrome due to a large left adrenal tumor (ACC) and a smaller right adrenal nodule.
Both adrenal lesions showed increased 18F-FDG uptake on PET-CT.
Following bilateral adrenalectomy with R0 resection, she experienced initial improvement.

Findings:

Two months post-surgery, the patient developed recurrent hypercortisolism.
Multiple liver and lung metastases were detected via imaging.
No local recurrence was evident, suggesting rapid systemic spread.

Implications:

This case underscores the potential for aggressive, early metastasis in ACC, even after apparent complete resection.
It highlights the importance of vigilant surveillance for distant recurrence in ACC patients.
Functional adrenal metastases can cause rapid disease progression and recurrence of Cushing's syndrome.