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A Virtual Data Repository Stimulates Data Sharing in a Consortium.

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The Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO) created a virtual data repository (VDR) to combine data and specimens from nine NIDA-funded cohorts. This VDR supports research on substance use and HIV/AIDS.

Keywords:
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Area of Science:

  • * Public Health
  • * Data Science
  • * Biomedical Research

Background:

  • * Research data often extends beyond original study objectives.
  • * Combining data from multiple cohorts presents unique challenges.
  • * The National Institute on Drug Abuse (NIDA) funds diverse research cohorts.

Purpose of the Study:

  • * To establish a virtual data repository (VDR) integrating data and specimens from NIDA-funded cohorts.
  • * To facilitate access to combined data for a wide range of research proposals.
  • * To support high-priority research on HIV/AIDS in the context of substance use.

Main Methods:

  • * Developed a virtual data repository (VDR) by addressing unique data integration challenges.
  • * Established common data elements and mapped data to a common set of values.
  • * Implemented bioethical controls, standard operating procedures, and data use agreements for data protection and handling.

Main Results:

  • * Loaded data from eight cohorts into a relational database, including substance use, participant data, and available specimens.
  • * Identified 6,177 actively followed participants as of January 2020.
  • * Cataloged 70,391 biospecimens with accompanying sociodemographic and clinical data.

Conclusions:

  • * The C3PNO VDR provides a publicly accessible, searchable database (www.c3pno.org).
  • * The VDR supports both consortium and external investigators in addressing novel scientific questions.
  • * Facilitates research at the intersection of substance use and HIV/AIDS.