Related Experiment Video
Updated: Oct 5, 2025
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Acute presentation of multi-cystic peritoneal mesothelioma
Abstract:
Multi-cystic peritoneal mesothelioma (MCPM) is a rare intra-abdominal neoplasm that occurs most commonly in young females. The disease usually presents as an incidental finding or with sub-acute abdominal pain. The mainstay of treatment is complete excision; however, local recurrence frequently occurs and malignant transformation has been reported. We describe a unique case of MCPM that presented with acute abdominal pain. A 32-year-old female presented with a 24-hour history of abdominal pain. Computed tomography abdomen demonstrated a low-density mass with surrounding inflammatory changes anterior to the ascending colon, which was initially thought to represent an abscess. A percutaneous drain was inserted; however, only clear fluid was aspirated and the lesion did not resolve. The patient subsequently underwent laparoscopy which identified a cystic structure overlying the ascending colon. The structure was excised whole with histology demonstrating MCPM. The patient recovered from surgery and will undergo a period of surveillance.
Insights
Multi-cystic peritoneal mesothelioma (MCPM) is a rare abdominal neoplasm. This case highlights MCPM presenting as acute abdominal pain, a unique clinical manifestation requiring surgical intervention.
Area of Science:
- Oncology
- Pathology
- Surgical Gastroenterology
Background:
- Multi-cystic peritoneal mesothelioma (MCPM) is an uncommon intra-abdominal neoplasm.
- MCPM typically affects young females and often presents asymptomatically or with mild abdominal pain.
- Complete surgical excision is the primary treatment, though recurrence and malignant transformation are concerns.
Observation:
- A 32-year-old female presented with acute abdominal pain.
- Initial CT imaging suggested an abscess, but percutaneous drainage yielded only clear fluid.
- Laparoscopy revealed a cystic mass over the ascending colon.
Findings:
- Histological examination confirmed the cystic mass as Multi-cystic peritoneal mesothelioma (MCPM).
- The patient underwent successful surgical excision of the MCPM.
- The patient experienced a favorable recovery and will undergo surveillance.
Implications:
- This case underscores the importance of considering MCPM in the differential diagnosis of acute abdominal pain in young women.
- Early and complete surgical resection is crucial for managing MCPM.
- Ongoing surveillance is necessary due to the potential for recurrence and malignant transformation.
