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Updated: Aug 7, 2026

GENPLAT: an Automated Platform for Biomass Enzyme Discovery and Cocktail Optimization
Published on: October 24, 2011
Unnatural cyclodextrins can be accessed from enzyme-mediated dynamic combinatorial libraries
Dennis Larsen1, Michel Ferreira2, Sébastien Tilloy2
1Department of Chemistry, Technical University of Denmark, Kongens Lyngby DK-2800, Denmark. denl@kemi.dtu.dk.
Abstract:
Dynamic systems of cyclodextrins (CDs) enabled by a native cyclodextrin glucanotransferase (CGTase) can incorporate unnatural glucopyranose-derived building blocks, expanding the applicability of enzyme-mediated dynamic combinatorial chemistry by using synthetically modified substrates. Starting dynamic combinatorial libraries from CDs with a single 6-modified glucopyranose results in a dynamic mixture of CDs containing several modified glucopyranoses. The relative concentrations of modified α, β or γ-CDs can be controlled by the addition of templates, providing a novel way to access modified CDs.
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