[Technologies for early diagnosis of oral mucosal diseases]

Expert evaluation of minimally invasive techniques in the diagnostic algorithm of pathological processes of the oral mucosa.

Fluorescence stomatoscopy of the oral mucosa of 1520 patients aged 18-65 years with analysis of color code of optical images was carried out. The nature of the disease was established by liquid cytology. PCR diagnostics was performed to detect oral-potential disorders provoked by human papillomavirus and Epstein-Barr virus.

Analysis of optical images of the normal and pathologically affected oral mucosa allows determining the possibilities of the technique to detect a hidden pathological process at the preclinical level. The results of liquid cytology in each case confirm the nature and depth of the pathological process. PCR diagnostics determines the presence of risk factors (Epstein-Barr virus, human papilloma virus 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59), contributing to the malignant transformation.

A comprehensive examination of the oral mucosa using clinical-laboratory methods of visualizing pathological processes contributes to their early diagnosis, reduces the risk of advanced cases of oncopathology and allows extending life expectancy.