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Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum
Meng Guo1, Kai Yang1,2, Nancy D Kock3
1Medical College of Wisconsin, Wauwatosa, USA.
Hand (New York, N.Y.)
|January 27, 2022
Summary
Collagenase clostridium histolyticum (CCH) injections do not alter the histological structure of Dupuytren disease cords. This study found no significant histopathological differences between injected and uninjected Dupuytren cords.
Area of Science:
- Orthopedics
- Rheumatology
- Dermatology
Background:
- Dupuytren disease involves palmar fascia thickening, causing hand function impairment.
- Collagenase clostridium histolyticum (CCH) injection is a minimally invasive treatment for Dupuytren cords.
- Histological effects of CCH on Dupuytren cords remain under-investigated.
Purpose of the Study:
- To evaluate the histological impact of CCH injection on Dupuytren cords.
- To compare the histology of CCH-injected cords with uninjected cords and normal palmar fascia.
Main Methods:
- Histological examination of 10 CCH-injected Dupuytren cords.
- Comparative analysis of cellularity, architecture, and connective tissue organization.
- Comparison against uninjected Dupuytren cords and normal palmar fascia tissue.
Main Results:
- No significant histopathological differences were observed between CCH-injected and uninjected Dupuytren cords.
- Histology of CCH-treated cords remained comparable to untreated cords.
Conclusions:
- Dupuytren cords do not exhibit histological alterations following CCH injection.
- Prior CCH exposure does not induce discernible changes in Dupuytren cord histology.
