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NSAID-exacerbated respiratory disease: a population study
Heidi Andersén1,2,3, Pinja Ilmarinen1,4, Jasmin Honkamäki1
1Faculty of Medicine and Health Technology, Tampere University Respiratory Research Group, Tampere University, Tampere, Finland.
ERJ Open Research
|January 27, 2022
Summary
NSAID-exacerbated respiratory disease (N-ERD) affects 1.4% of adults. Risk factors include older age, family history, and environmental exposures, leading to significant respiratory morbidity.
Area of Science:
- Allergy and Clinical Immunology
- Respiratory Medicine
- Epidemiology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) can worsen respiratory conditions.
- NSAID-exacerbated respiratory disease (N-ERD) is a hypersensitivity linked to asthma or chronic rhinosinusitis.
- A European position paper recommended the N-ERD acronym.
Purpose of the Study:
- To determine the prevalence of N-ERD in a Finnish adult population.
- To identify factors associated with N-ERD.
- To assess the clinical impact of N-ERD.
Main Methods:
- A cross-sectional questionnaire survey was conducted in 2016.
- The study included 16,000 randomly selected adults aged 20-69 years in Finland.
- The response rate was 51.5%.
Main Results:
- The prevalence of N-ERD was 1.4%; aspirin-exacerbated respiratory disease (AERD) was 0.7%.
- N-ERD prevalence was 6.9% in asthmatics and 2.7% in those with rhinitis.
- Risk factors included older age, family history of respiratory allergies, smoking, and pollution exposure. N-ERD correlated with increased respiratory symptoms, severe reactions, and hospitalizations.
Conclusions:
- N-ERD affects 1.4% of the Finnish adult population.
- Older age, family history, and environmental exposures (smoking, pollutants) increase N-ERD risk.
- N-ERD is associated with considerable respiratory morbidity.
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