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Association between case management and longitudinal decrease in negative symptoms in patients with first episode
Lorenzo Pelizza1, Davide Maestri1, Emanuela Leuci1
1Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Parma, Italy.
Early Intervention in Psychiatry
|January 27, 2022
Summary
Negative symptoms in first episode psychosis (FEP) improve with early intervention services. Case management sessions significantly predicted symptom reduction, highlighting the importance of integrated care.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Negative symptoms (NS) significantly impair functioning in individuals with psychosis, even at onset.
- Research on treating NS in early psychosis is limited, with most studies focusing on chronic conditions.
- Psychosocial rehabilitation for NS in first episode psychosis (FEP) requires further investigation.
Purpose of the Study:
- To longitudinally assess the stability of NS in FEP over a 2-year period.
- To investigate the association between NS levels and specific components of an early intervention in psychosis (EIP) protocol.
Main Methods:
- 266 FEP subjects (aged 12-35 years) were assessed at baseline using the Positive and Negative Syndrome Scale (PANSS).
- Longitudinal data were collected over a 2-year follow-up period.
- Multiple linear regression analyses were employed to examine associations.
Main Results:
- Participants showed significant improvement in NS over the 2-year follow-up.
- Increased case management sessions within the EIP protocol predicted NS improvement.
- Shorter duration of untreated psychosis and reduced depressive/positive symptoms also predicted NS improvement.
- No association was found between NS improvement and antipsychotic medication.
Conclusions:
- NS are clinically significant in FEP at presentation.
- NS severity can improve over time with integrated, patient-tailored EIP case management.
- Early intervention and case management are crucial for addressing NS in FEP.
Keywords:
case managementearly intervention in psychosisfirst episode psychosisnegative symptomstreatment responseMore Related Videos
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