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Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles
Manuel Bañó-Polo1, Luis Martínez-Gil2, Manuel M Sánchez Del Pino2
1Department of Microbiology. Dentaid Research Center, Cerdanyola del Vallès, Barcelona, Spain.
Background:
SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.
Aim Of The Study:
To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.
Methods:
SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.
Results:
Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.
Conclusion:
Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
