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Nanotechnology in Drug Delivery for Liver Fibrosis

Lihong Gu¹, Feng Zhang¹, Jinhui Wu^2,3

¹Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.

Frontiers in Molecular Biosciences

|January 28, 2022

Abstract:

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.

Keywords:

chronic liver diseases liver fibrosis nanomedicine nanotechnology targeted drug delivery

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