Related Experiment Video
Updated: Oct 5, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Cascade Sensitivity Measures
Silvana M Pesenti1, Pietro Millossovich2,3, Andreas Tsanakas3
1Department of Statistical Sciences, University of Toronto, 700 University Avenue, Toronto, Ontario, M5G 1X6, Canada.
Abstract:
In risk analysis, sensitivity measures quantify the extent to which the probability distribution of a model output is affected by changes (stresses) in individual random input factors. For input factors that are statistically dependent, we argue that a stress on one input should also precipitate stresses in other input factors. We introduce a novel sensitivity measure, termed cascade sensitivity, defined as a derivative of a risk measure applied on the output, in the direction of an input factor. The derivative is taken after suitably transforming the random vector of inputs, thus explicitly capturing the direct impact of the stressed input factor, as well as indirect effects via other inputs. Furthermore, alternative representations of the cascade sensitivity measure are derived, allowing us to address practical issues, such as incomplete specification of the model and high computational costs. The applicability of the methodology is illustrated through the analysis of a commercially used insurance risk model.
Related Concept Videos
Censoring Survival Data
Desensitization and Tachyphylaxis
Assumptions of Survival Analysis
Design Example: Analyzing Capacity Contours for Flood Risk Assessment
Frequency-dependent Selection
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...

