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Predictive Value of Complete Blood Count-Derived Inflammatory Markers for 5-Year Survival After Carotid

Núria Casanova1,2, Carles Diaz-Duran1, Lluís Nieto1

  • 1Vascular Surgery Department, 16548Hospital del Mar, Barcelona, Spain.

Angiology
|January 28, 2022
PubMed

Insights

Preoperative complete blood count inflammatory markers (CBC-IMs) like NLR, PLR, and SII are linked to 5-year survival after carotid endarterectomy (CEA). These markers may aid in selecting patients for this vital preventive procedure.

Area of Science:

  • Vascular Surgery
  • Inflammatory Biomarkers
  • Cardiovascular Disease Prediction

Background:

  • Complete blood count inflammatory markers (CBC-IMs) are linked to cardiovascular disease and mortality.
  • Predicting long-term outcomes after carotid endarterectomy (CEA) is crucial for patient management.

Purpose of the Study:

  • To evaluate the relationship between preoperative CBC-IMs and 5-year survival following CEA.
  • To determine if CBC-IMs can improve risk stratification in patients undergoing CEA.

Main Methods:

  • Retrospective analysis of 411 patients undergoing CEA (2004-2018).
  • Assessment of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte (LMR) ratio, and systemic immune-inflammation index (SII).
  • Multivariable Cox regression and spline analysis to identify predictors of 5-year survival.

Main Results:

  • The 5-year survival rate was 79.8%.
  • Age, hemoglobin, heart failure, ASA-IV score, and active neoplastic disease were independent predictors of survival.
  • NLR, PLR, and SII demonstrated a linear and independent relationship with 5-year survival after adjusting for baseline predictors.
  • Inclusion of NLR, PLR, and SII improved the continuous net reclassification index (c-NRI), indicating enhanced predictive ability.

Conclusions:

  • Preoperative CBC-IMs, including NLR, PLR, and SII, are significantly associated with 5-year survival after CEA.
  • These inflammatory markers may offer moderate value in patient selection for CEA.
  • Further research could explore integrating CBC-IMs into routine risk assessment for CEA patients.

Keywords:
carotid endarterectomyinflammationprognosis

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