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Targeting mitochondria as a therapeutic anti-gastric cancer approach

Peticha Tanprasert1, Sirikan Limpakan Yamada1, Siriporn C Chattipakorn2,3

  • 1Division of Gastrointestinal Surgery and Endoscopy, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Apoptosis : an International Journal on Programmed Cell Death
|January 28, 2022
PubMed

Insights

Mitochondria are crucial for gastric cancer cell survival and death. Targeting mitochondrial dynamics offers a promising new avenue for treating gastric cancer, improving outcomes beyond current chemotherapy.

Area of Science:

  • Oncology
  • Cell Biology
  • Mitochondrial Biology

Background:

  • Gastric cancer is a leading cause of cancer death worldwide.
  • Current chemotherapy for advanced gastric cancer has limited efficacy.
  • Mitochondria are vital for cell survival, apoptosis, and cancer development.

Purpose of the Study:

  • To review the role of mitochondrial homeostasis in gastric cancer.
  • To explore targeting mitochondrial dynamics as a therapeutic strategy for gastric cancer.

Main Methods:

  • Comprehensive literature review on mitochondrial function in gastric cancer.
  • Analysis of studies on mitochondrial dynamics (fission, fusion, mitophagy) in carcinogenesis.
  • Discussion of potential therapeutic interventions targeting mitochondria.

Main Results:

  • Mitochondria significantly influence gastric cancer cell fate and progression.
  • Mitochondrial dynamics, including fission, fusion, and mitophagy, are implicated in cancer development.
  • Targeting these dynamics presents a novel therapeutic approach.

Conclusions:

  • Understanding mitochondrial homeostasis is key to developing new gastric cancer treatments.
  • Targeting mitochondrial dynamics holds significant potential for overcoming chemotherapy resistance and improving patient outcomes.
Keywords:
ApoptosisCell deathGastric cancerMitochondriaROS

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