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Unraveling B cell trajectories at single cell resolution
Dhakshayini Morgan1, Vinay Tergaonkar2
1Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673, Singapore; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, 119 074, Singapore.
Trends in Immunology
|January 29, 2022
Summary
Single cell technologies reveal B cell gene signatures and biomarkers for understanding immune responses and developing new therapies for autoimmune diseases and cancers.
Area of Science:
- Immunology
- Cell Biology
- Genomics
Background:
- B cells are crucial for adaptive immunity, differentiating into memory or plasma cells to produce antibodies and activate T cells.
- Dysfunctional B cells are implicated in autoimmune diseases and cancers.
- Single cell technologies offer unprecedented resolution into B cell biology.
Purpose of the Study:
- To review the application of single cell approaches in B cell research.
- To highlight the identification of B cell gene signatures and biomarkers.
- To discuss the potential for future therapeutic discoveries.
Main Methods:
- Utilizing single cell genomics, transcriptomics, and proteomics.
- Analyzing B cell populations in both normal and diseased tissues.
- Identifying distinct gene signatures and biomarkers.
Main Results:
- Single cell technologies enable detailed analysis of B cell development and differentiation.
- Identification of specific B cell gene signatures and biomarkers in various conditions.
- Insights into B cell responses during homeostasis, infection, and disease.
Conclusions:
- Single cell approaches provide deeper insights into mammalian B cell biology.
- Identified gene signatures and biomarkers can inform therapeutic strategies.
- This review underscores the benefits for future drug discovery in B cell-related disorders.
