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Accelerating joint relaxation-diffusion MRI by integrating time division multiplexing and simultaneous multi-slice
Yang Ji1,2, W Scott Hoge3, Borjan Gagoski4
1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Magnetic Resonance in Medicine
|January 29, 2022
Summary
This study integrates time-division multiplexing (TDM) with simultaneous multi-slice (SMS) imaging to accelerate relaxation-diffusion MRI scans. The new TDM-SMS technique achieves high acceleration without sacrificing image quality, making it feasible for neuroimaging research.
Area of Science:
- Magnetic Resonance Imaging (MRI)
- Neuroimaging
- Diffusion Tensor Imaging (DTI)
Background:
- Relaxation-diffusion MRI is crucial for studying brain microstructure.
- Current acquisition methods, like simultaneous multi-slice (SMS) echo-planar imaging (EPI), face limitations in acceleration speed.
- Accelerating acquisition is vital for improving efficiency in neuroimaging research.
Purpose of the Study:
- To accelerate relaxation-diffusion imaging acquisition by integrating time-division multiplexing (TDM) with SMS for EPI.
- To evaluate the imaging quality and diffusion measures obtained with the integrated TDM-SMS technique.
Main Methods:
- Developed two variants of the TDM-SMS sequence: TDM3e-SMS and TDM2s-SMS.
- Achieved high slice-acceleration factors (e.g., 6x) by combining TDM and SMS.
- Evaluated sequences on a 3T scanner using in vivo human brains, comparing with standard single-band (SB)-EPI and SMS-EPI.
Main Results:
- TDM3e-SMS (6x acceleration) showed similar image intensity and microstructure measures to SMS-EPI (MB=2) and less intensity bias than SMS-EPI (MB=4).
- Consistent correlations between echo time (TE) and mean kurtosis (MK)/mean diffusivity (MD) were observed across sequences in white matter.
- TDM2s-SMS (4x acceleration) provided similar diffusion imaging measures to standard SMS-EPI (MB=2).
Conclusions:
- The TDM-SMS sequence offers 2x to 3x additional acceleration to SMS without compromising imaging quality.
- Significant scan time reduction with TDM-SMS makes joint relaxation-diffusion MRI feasible for neuroimaging.
- This technique can facilitate the investigation of new biomarkers for brain disorders.
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