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Related Experiment Video

Updated: Apr 9, 2026

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PRIME: Phase reversed interleaved multi-Echo acquisition enables highly accelerated distortion-corrected diffusion

Yohan Jun1, Qiang Liu2, Ting Gong3

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States; Department of Radiology, Harvard Medical School, Boston, MA, United States; Pediatric Imaging Research Center, Massachusetts General Hospital, Boston, MA, United States.

Medical Image Analysis
|April 7, 2026
PubMed
Summary

This study introduces the PRIME pulse sequence for faster, high-resolution diffusion MRI (dMRI) with distortion correction. PRIME achieves this by adding echoes without increasing scan time, improving image quality and enabling advanced analyses.

Keywords:
Diffusion MRIDiffusion relaxometryDistortion correctionField mapMesoscale

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Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging Techniques
  • Biomedical Engineering

Background:

  • High-resolution diffusion MRI (dMRI) faces challenges balancing geometric distortion, signal-to-noise ratio (SNR), and scan efficiency.
  • Existing methods often struggle to achieve high resolution and distortion correction simultaneously without compromising scan speed.

Purpose of the Study:

  • To develop and evaluate a novel pulse sequence for accelerated, distortion-corrected dMRI.
  • To leverage additional echoes within existing scan times for enhanced data acquisition and correction.

Main Methods:

  • Developed a phase-reversed interleaved multi-echo acquisition (PRIME) sequence integrated with generalized slice dithered enhanced resolution (gSlider) encoding.
  • Utilized multiple echoes for high-fidelity field map estimation, phase navigation, motion correction, and diffusion relaxometry.
  • Evaluated the sequence on in vivo human data using clinical and Connectome 2.0 MRI scanners.

Main Results:

  • Achieved high in-plane acceleration using field maps from a lower-resolution second echo.
  • Enabled high-resolution diffusion relaxometry parameter estimation using triple-echo PRIME data.
  • Acquired high-fidelity mesoscale diffusion-weighted imaging (DWI) at 490 µm isotropic resolution in vivo.

Conclusions:

  • The PRIME sequence offers a solution for highly accelerated, distortion-corrected, high-resolution dMRI.
  • PRIME effectively utilizes additional echoes to improve image quality and enable advanced diffusion MRI applications without extending scan duration.
  • This technique holds promise for more efficient and comprehensive brain imaging in clinical and research settings.