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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
Proceedings from the 3rd International Conference on Microbiome Engineering
Sandra McClure1, Fatima Enam2, Jack Arnold3
1Committee on Molecular Metabolism & Nutrition, the University of Chicago, Chicago, Illinois, USA.
Microbiome engineering offers precise control over the human microbiome for disease understanding and novel therapeutics. This field is rapidly advancing with engineered microbes, probiotics, and bacteriophages.
Area of Science:
- Microbiome Engineering
- Synthetic Biology
- Human Physiology
Background:
- The human microbiome significantly influences multiple physiological processes.
- Engineering the microbiome presents opportunities for disease etiology research and therapeutic development.
- Current microbiome research is nascent, but engineering efforts are accelerating translation.
Purpose of the Study:
- To present state-of-the-art advancements in microbiome engineering.
- To discuss novel approaches for controlling microbiome composition and activity.
- To highlight the potential of microbiome engineering for diagnostics and therapeutics.
Main Methods:
- Review of cutting-edge research presented at the 3rd International Conference on Microbiome Engineering.
- Discussion of various microbiome engineering strategies including probiotics and prebiotics.
- Exploration of engineered microbes, microbially derived biomolecules, and bacteriophage applications.
Main Results:
- Experts showcased diverse microbiome engineering techniques.
- The conference highlighted the potential of engineered microbes and bacteriophages.
- Advancements in probiotics and prebiotics were discussed.
Conclusions:
- Microbiome engineering is a rapidly evolving field with significant therapeutic and diagnostic potential.
- Precise control over the microbiome is key to unlocking its full potential.
- Continued innovation in microbiome engineering promises to revolutionize healthcare.
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