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Multi-antibacterial agent-based electrospun polycaprolactone for active wound dressing.

Fatemeh Safdari1, Maryam Darya Gholipour1, Azam Ghadami2

  • 1Department of Chemical and Polymer Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Progress in Biomaterials
|January 30, 2022
PubMed
Summary
This summary is machine-generated.

Novel electrospun nanofibers incorporating natural antibacterial compounds like curcumin, piperine, and eugenol show promise for advanced wound dressings. These systems demonstrate effective antibacterial activity and suitable properties for wound healing applications.

Keywords:
Antibacterial wound dressingCurcuminElectrospun polycaprolactoneRutin

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmacology

Background:

  • Increasing demand for natural compounds in medicine due to chemical drug side effects.
  • Importance of advanced wound dressing fabrication for efficient wound healing.
  • Potential of electrospinning for creating nanofibrous materials for biomedical applications.

Purpose of the Study:

  • To develop novel, multi-component electrospun nanofibers incorporating natural antibacterial agents.
  • To investigate the synergistic effects of curcumin, piperine, eugenol, and rutin in polycaprolactone nanofibers.
  • To evaluate the suitability of these nanofiber systems as wound dressings.

Main Methods:

  • Electrospinning of polycaprolactone (PCL) nanofibers.
  • Loading of natural antibacterial compounds: curcumin, piperine, eugenol, and rutin.
  • Fabrication of one-, two-, and three-component systems (PCPiEu, PCPiR).
  • Characterization of nanofiber morphology, water absorption, water vapor permeability, and mechanical properties.
  • In vitro antibacterial activity testing against Staphylococcus aureus and Enterococcus faecalis.

Main Results:

  • Optimized electrospinning produced smooth, bead-free nanofibers with diameters of 198.38 nm (PCPiEu) and 142.60 nm (PCPiR).
  • Three-component systems exhibited appropriate water absorption and vapor permeability for wound dressings (8.33-10.42 mg cm2 h-1).
  • PCPiEu and PCPiR samples demonstrated significant antibacterial activity, with killing rates of 74-75% against Gram-positive bacteria and 96.88-99.47% against Gram-negative bacteria.

Conclusions:

  • The developed multi-component electrospun nanofibers show excellent potential as advanced wound dressings.
  • Synergistic combinations of natural antibacterial compounds can enhance efficacy.
  • Further investigation is needed to address the reduced mechanical properties observed in the developed samples.