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A Review on the Role of SPRY4-IT1 in the Carcinogenesis

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Mohammad Taheri3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Oncology
|January 31, 2022
PubMed

Insights

Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1), a long non-coding RNA, promotes cancer by regulating cell growth and sequestering microRNAs. Its oncogenic roles are evident across various cancers and signaling pathways.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is a long non-coding RNA (lncRNA) involved in regulating cell growth, proliferation, and apoptosis.
  • SPRY4-IT1 plays a role in lipid biosynthesis by controlling lipin 2 levels.
  • This lncRNA exhibits oncogenic properties in various tissues.

Purpose of the Study:

  • To elucidate the role of SPRY4-IT1 in carcinogenesis.
  • To explore the mechanisms by which SPRY4-IT1 contributes to cancer development.
  • To investigate the interactions of SPRY4-IT1 with microRNAs and signaling pathways.

Main Methods:

  • Analysis of cell lines, xenograft models, and clinical studies.
  • Investigation of SPRY4-IT1's interaction with microRNAs (e.g., miR-101-3p).
  • Examination of SPRY4-IT1's functional associations with signaling pathways (e.g., HIF-1α, NF-κB/p65, AMPK, ZEB1, MAPK, PI3K/Akt).

Main Results:

  • SPRY4-IT1 acts as an oncogene in diverse tissues.
  • SPRY4-IT1 sequesters microRNAs, including miR-101-3p, contributing to carcinogenesis.
  • Evidence from cell lines, xenografts, and clinical studies supports SPRY4-IT1's oncogenic role and its interactions with key signaling pathways.

Conclusions:

  • SPRY4-IT1 is implicated in the carcinogenesis process through microRNA sponging and modulation of cellular signaling pathways.
  • The findings highlight SPRY4-IT1 as a potential therapeutic target in various cancers.
  • Further research into SPRY4-IT1's functions can advance our understanding of cancer biology.
Keywords:
SPRY4-IT1biomarkercancercarcinogenesisexpression

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