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Primary adrenal diffuse large B-cell lymphoma with normal adrenal cortex function: A case report.
Zhi-Nan Fan1, Hong-Jin Shi1, Bo-Bo Xiong1
1Department of Urology, The Second Affiliated Hospital, Kunming Medical University, Kunming 650000, Yunnan Province, China.
World Journal of Clinical Cases
|January 31, 2022
Summary
Primary adrenal diffuse large B-cell lymphoma is rare. While R-CHOP is the standard treatment, surgery aids diagnosis, but optimal treatment remains uncertain.
Area of Science:
- Oncology
- Hematology
- Surgical Pathology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma, representing 30-40% of cases.
- Primary adrenal DLBCL is an exceptionally rare clinical presentation.
Observation:
- A 73-year-old male presented with abdominal pain and fatigue.
- CT imaging revealed large, irregular masses on both adrenal glands.
- Pathological diagnosis confirmed diffuse large B-cell lymphoma of the adrenal gland.
Findings:
- The patient underwent left adrenal gland resection followed by R-CHOP immunochemotherapy.
- Despite treatment, the patient's condition worsened, leading to death from respiratory failure.
- R-CHOP is the current standard immunochemotherapy for primary adrenal DLBCL.
Implications:
- Surgery plays a crucial role in the diagnosis of primary adrenal DLBCL.
- The optimal therapeutic strategy for primary adrenal DLBCL requires further investigation.
- This case highlights the aggressive nature and diagnostic challenges of rare adrenal lymphomas.
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