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Aerobic Exercise in HIV-Associated Neurocognitive Disorders: Protocol for a Randomized Controlled Trial
Martins Nweke1, Nombeko Mshunqane2, Nalini Govender3
1Department of Physiotherapy, Faculty of Health Sciences, University of Pretoria, Enugu, Nigeria.
JMIR Research Protocols
|January 31, 2022
Summary
Aerobic exercise may improve neurocognitive function in people living with HIV and HIV-associated neurocognitive disorder (HAND). This randomized controlled trial will assess the impact of a 12-week exercise program on HAND symptoms and related outcomes in Nigeria.
Area of Science:
- Neuroscience
- Public Health
- Exercise Science
Background:
- Antiretroviral therapy (ART) has reduced HIV-associated dementia but not less severe HIV-associated neurocognitive disorder (HAND).
- People living with HIV on ART may still experience limiting HAND symptoms.
- Aerobic exercise is being investigated as a potential intervention for HAND.
Purpose of the Study:
- To determine the effects of a 12-week aerobic exercise program on HAND in Southeastern Nigeria.
- To evaluate neurocognitive performance, HAND prevalence, viral load, and CD4 count in participants.
- To assess secondary outcomes including quality of life and activity limitations.
Main Methods:
- A randomized controlled trial involving at least 68 patients diagnosed with HAND.
- Participants assigned to either an aerobic exercise group (stationary bicycle ergometer, 3x/week, 12 weeks) or a control group.
- Primary outcomes: neurocognitive performance, HAND prevalence, viral load, CD4 count. Secondary outcomes: quality of life, activity/social participation.
Main Results:
- Data curation is ongoing; analysis is pending.
- Study outcomes are expected to be published in March 2022.
- This is a protocol for an ongoing study.
Conclusions:
- A 12-week aerobic exercise program is being evaluated for its effect on HAND in Southeastern Nigeria.
- The study protocol is registered and approved.
- Further results will be published upon completion of data analysis.
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