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Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

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Interrelation between swelling, mechanical constraints and reaction-diffusion processes in molecular responsive

Eleonóra Parelius Jonášová¹, Bjørn Torger Stokke¹, Victorien Prot²

¹Biophysics and Medical Technology, Department of Physics, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

|January 31, 2022

Summary

We developed a finite element model for molecular responsive hydrogels, coupling diffusion, reaction, and mechanical deformation. This model accurately predicts hydrogel swelling dynamics influenced by molecular stimuli.

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Area of Science:

Polymer Science
Materials Science
Biomaterials Engineering

Background:

Molecular responsive hydrogels exhibit swelling dynamics governed by species transport, network reactions, and relaxation.
Oligonucleotide duplexes serve as physical crosslinks in acrylamide-based hydrogels, susceptible to molecular destabilization.

Purpose of the Study:

To develop a finite element modeling approach for hydrogels with oligonucleotide crosslinks.
To couple diffusion, reaction, and mechanical deformation processes in molecular responsive hydrogels.

Main Methods:

Finite element modeling approach coupling diffusion, reaction, and network relaxation.
Modeling hydrogels with DNA or oligomorpholino (MO) crosslinks, destabilized by competitive displacement.
Coupling reaction-diffusion with mechanical deformations and constraints.

Main Results:

Numerical examples demonstrate the significance of coupling reaction-diffusion with mechanical deformations.
The model was validated against experimental swelling data of hemi-spheroidal hydrogels.
Reaction-diffusion model parameters were derived by fitting to experimental data using varying molecular stimuli.

Conclusions:

The developed finite element model effectively captures the swelling dynamics of molecular responsive hydrogels.
Coupling reaction-diffusion with mechanical aspects is crucial for accurate hydrogel behavior prediction.
The model provides a framework for designing and optimizing molecular responsive hydrogels for specific applications.