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E3 ligases: a potential multi-drug target for different types of cancers and neurological disorders

Konda Mani Saravanan1, Muthu Kannan2, Prabhakar Meera3

  • 1Research and Development Wing, Bharath Institute of Higher Education and Research, Chennai, 600073, Tamil Nadu, India.

Future Medicinal Chemistry
|January 31, 2022
PubMed

Insights

E3 ubiquitin ligases are crucial for cellular processes and disease. This review explores their characteristics, classification, and roles in diseases like cancer and neurological disorders, offering resources for researchers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Biology

Background:

  • Ubiquitylation is a vital posttranslational protein modification essential for numerous cellular functions.
  • The ubiquitin-proteasome system, involving E1, E2, and E3 enzymes, regulates protein degradation and cellular signaling.
  • E3 ubiquitin ligases play a critical role in substrate specificity within this pathway.

Purpose of the Study:

  • To provide a comprehensive overview of E3 ubiquitin ligases.
  • To explore their structural characteristics and classification.
  • To detail their involvement in major diseases and biological system failures.

Main Methods:

  • Literature review of E3 ubiquitin ligase functions and disease associations.
  • Classification of E3 ligases based on structural domains.
  • Identification and curation of online data resources for researchers.

Main Results:

  • Detailed characterization of E3 ubiquitin ligase families and their structural domains.
  • Explanation of the enzymatic cascade for ubiquitin transfer to target proteins.
  • Identification of E3 ligase dysregulation in cancers and neurological disorders.

Conclusions:

  • E3 ubiquitin ligases are key regulators implicated in the pathogenesis of severe diseases.
  • Understanding E3 ligase biology is crucial for developing therapeutic strategies.
  • Online resources can facilitate further research into E3 ubiquitin ligase functions and disease relevance.
Keywords:
cancer and neurological disordercrug targetsligasesposttranslational modificationubiquitylation

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