Related Experiment Video

Updated: Oct 5, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion

Rami M Abazid1, Yasmine T Sallam2, Jonathan G Romsa3

  • 1Division of Nuclear Medicine, Section of Cardiac Hybrid Imaging, Victoria Hospital, London Health Sciences Centre, 800 Commissioners Road East, PO Box 5010, London, ON, N6A 5W9, Canada. ramiabazid@yahoo.com.

European Journal of Hybrid Imaging
|February 1, 2022
PubMed

Insights

Coronary computed tomography angiography (CCTA) complements SPECT myocardial perfusion imaging (MPI) in detecting myocardial necrosis. CCTA adds specificity to diagnosing fixed perfusion defects after myocardial infarction.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Myocardial necrosis assessment is crucial after ST-segment elevation myocardial infarction (STEMI).
  • Coronary revascularization is a standard treatment for STEMI.
  • Accurate detection of myocardial necrosis aids in patient management and prognosis.

Purpose of the Study:

  • To explore the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI).
  • To evaluate the added value of CCTA in detecting myocardial necrosis in patients with prior STEMI and revascularization.

Main Methods:

  • A retrospective analysis of 144 patients with a history of STEMI treated with coronary revascularization.
  • Evaluation of both CCTA and MPI scans to identify myocardial necrosis.
  • Comparison of findings between CCTA and MPI to determine CCTA's added value.

Main Results:

  • Five patients with patent stents/bypass grafts showed fixed perfusion defects on MPI and sub-endocardial hypoperfusion on CCTA.
  • A close correlation was observed between the extent and location of perfusion defects on CCTA and SPECT MPI.
  • CCTA identified specific areas of myocardial necrosis consistent with MPI findings.

Conclusions:

  • CCTA and SPECT MPI play a complementary role in assessing fixed perfusion defects.
  • CCTA enhances the specificity of diagnosing myocardial necrosis when used alongside MPI.
  • Hybrid imaging approaches can improve the diagnostic accuracy of myocardial necrosis detection.
Abstract

Keywords:
Coronary CT angiographyPerfusion defectsSPECT

More Related Videos

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

32.8K
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

3.9K

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
88
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
36
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
185
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.1K
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
413