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Coagulation in gout: is there a link with disease activity?

Daisy Vedder1,2, Martijn Gerritsen3, Joost C M Meijers4,5

  • 1Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands. d.vedder@reade.nl.

Clinical Rheumatology
|February 1, 2022
PubMed

Insights

Patients with active gout show higher thrombin generation markers, suggesting a link between gout disease activity and coagulation. However, changes in disease activity over one year did not significantly alter coagulation markers, possibly due to persistent inflammation.

Area of Science:

  • Rheumatology
  • Hematology
  • Cardiovascular Medicine

Background:

  • Gout is a chronic inflammatory condition associated with an increased risk of cardiovascular events.
  • The relationship between gout disease activity and the coagulation system requires further elucidation.

Purpose of the Study:

  • To investigate coagulation markers in gout patients.
  • To explore associations between gout disease activity and coagulation marker levels.

Main Methods:

  • A prospective cohort study involving 30 Dutch gout patients.
  • Analysis of coagulation markers (APTT, PT, D-dimer, prothrombin F1+2, vWF, thrombin generation) at baseline and 1-year follow-up.
  • Correlation of coagulation markers with gout disease activity using the Gout Activity Score (GAS).

Main Results:

  • Higher Gout Activity Score (GAS) correlated with increased thrombin generation parameters (ETP, peak thrombin, velocity index).
  • Tophaceous gout and elevated serum uric acid (SUA) levels were linked to thrombin generation.
  • Despite a moderate decrease in disease activity over one year, thrombin generation parameters showed a slight procoagulant trend.

Conclusions:

  • Active gout is associated with elevated thrombin generation markers, indicating a connection between disease activity and coagulation.
  • Changes in gout disease activity over one year did not lead to significant alterations in coagulation markers, potentially due to ongoing low-grade inflammation.
  • Further research is recommended to compare coagulation marker levels in gout patients with the general population and to assess the impact of effective gout treatment.
Abstract

Keywords:
Cardiovascular diseaseCoagulationDisease activityGoutInflammation

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