Related Experiment Video
Updated: Oct 5, 2025
04:56
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
Published on: August 4, 2023
905
Coagulation in gout: is there a link with disease activity?
Daisy Vedder1,2, Martijn Gerritsen3, Joost C M Meijers4,5
1Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands. d.vedder@reade.nl.
Clinical Rheumatology
|February 1, 2022
Summary
Patients with active gout show higher thrombin generation markers, suggesting a link between gout disease activity and coagulation. However, changes in disease activity over one year did not significantly alter coagulation markers, possibly due to persistent inflammation.
Area of Science:
- Rheumatology
- Hematology
- Cardiovascular Medicine
Background:
- Gout is a chronic inflammatory condition associated with an increased risk of cardiovascular events.
- The relationship between gout disease activity and the coagulation system requires further elucidation.
Purpose of the Study:
- To investigate coagulation markers in gout patients.
- To explore associations between gout disease activity and coagulation marker levels.
Main Methods:
- A prospective cohort study involving 30 Dutch gout patients.
- Analysis of coagulation markers (APTT, PT, D-dimer, prothrombin F1+2, vWF, thrombin generation) at baseline and 1-year follow-up.
- Correlation of coagulation markers with gout disease activity using the Gout Activity Score (GAS).
Main Results:
- Higher Gout Activity Score (GAS) correlated with increased thrombin generation parameters (ETP, peak thrombin, velocity index).
- Tophaceous gout and elevated serum uric acid (SUA) levels were linked to thrombin generation.
- Despite a moderate decrease in disease activity over one year, thrombin generation parameters showed a slight procoagulant trend.
Conclusions:
- Active gout is associated with elevated thrombin generation markers, indicating a connection between disease activity and coagulation.
- Changes in gout disease activity over one year did not lead to significant alterations in coagulation markers, potentially due to ongoing low-grade inflammation.
- Further research is recommended to compare coagulation marker levels in gout patients with the general population and to assess the impact of effective gout treatment.
More Related Videos
07:09Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
11.6K
06:35An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
7.3K
Related Concept Videos
01:20Extrinsic and Intrinsic Pathways of Hemostasis
9.7K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
9.7K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
975
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
975
01:09Coagulation
7.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
7.7K
01:24Disorders of Hemostasis
1.3K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.3K
01:20The JAK-STAT Signaling Pathway
9.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.5K
01:05Introduction to Hemostasis
9.4K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
9.4K