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Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Multimodal Treatment Including Intracavitary Chemotherapy for Recurrent Pediatric Pleuropulmonary Blastoma

Merieme Habti1, Gervaise Hubert2, Monia Marzouki2

  • 1Pediatric Surgery, Université de Montréal, Montreal, CAN.

Cureus
|February 1, 2022
PubMed

Insights

Recurrent pleuropulmonary blastoma (PPB) in a child was successfully treated with surgery, chemotherapy, intrapleural cisplatin, and targeted therapy. This multimodal approach, including novel therapies, offers hope for managing rare pediatric cancers.

Area of Science:

  • Pediatric Oncology
  • Rare Cancers
  • Thoracic Surgery

Background:

  • Pleuropulmonary blastoma (PPB) is a rare and aggressive pediatric thoracic malignancy.
  • Recurrent PPB carries a poor prognosis despite advances in treatment.

Observation:

  • A 30-month-old female presented with recurrent pleuropulmonary blastoma.
  • The patient had previously undergone standard treatment modalities.

Findings:

  • The patient survived recurrent PPB following a multimodal treatment strategy.
  • This included surgery, adjuvant chemotherapy, intrapleural cisplatin infusion, and targeted therapy guided by whole exome sequencing (WES).

Implications:

  • Intrapleural cisplatin infusion and targeted therapy demonstrated safety and efficacy in this case.
  • These novel approaches can be considered as part of a multimodal strategy for recurrent PPB management.

Keywords:
intracavitary chemotherapyintrapleural cisplatinpleuropulmonary blastomapleuropulmonary blastoma recurrencetarget therapy oncology

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