[Complex evaluation of pancreatic function in insulin-dependent diabetes mellitus]

The time course of the concentration of immunoreactive insulin (IRI) and C-peptide in the plasma and erythrocytes and the blood sugar level in GTT per os were investigated. Altogether 73 healthy persons and 52 patients with a severe form of insulin-dependent diabetes mellitus were examined. To define the time course of changes in the concentration of the above values a rate gradient determined as a difference of changed concentration rate for the 1st and 2nd hour after load for each examined person, was proposed. The most significant differences in the healthy persons and patients were noted in the plasma IRI basal level and blood sugar basal levels. The rate gradient defined most completely the time course of carbohydrate metabolism. The gradients C-peptide had maximum difference in healthy persons and patients. The hormone and blood sugar levels characterized the condition of the examined persons, and rate gradients were indicative of the state of the blood sugar regulation system.