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Relationship between intracoronary thrombus burden and systemic immune-inflammation index in patients with ST-segment

Abdullah Kadir Dolu1, Orhan Karayiğit2, Can Ozkan3

  • 1Department of Cardiology, Izmir Katip Çelebi University Ataturk Education and Research Hospital, Izmir, Turkey.

Acta Cardiologica
|February 2, 2022
PubMed

Insights

The systemic immune-inflammation index (SII) effectively predicts high thrombus burden in ST-elevation myocardial infarction (STEMI) patients. SII demonstrates superior predictive capability compared to neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR).

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Intracoronary thrombus burden is a critical factor in ST-elevation myocardial infarction (STEMI).
  • Inflammatory markers, including neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), have been investigated as predictors in cardiovascular diseases.
  • The systemic immune-inflammation index (SII) is a composite marker reflecting systemic inflammation and immune cell status.

Purpose of the Study:

  • To evaluate the relationship between intracoronary thrombus burden and SII in STEMI patients undergoing primary percutaneous coronary intervention (PPCI).
  • To compare the predictive capacity of SII against NLR and PLR for high thrombus burden in this patient cohort.

Main Methods:

  • A total of 425 STEMI patients who underwent PPCI were analyzed.
  • Intracoronary thrombus burden was assessed using the Thrombolysis in Myocardial Infarction (TIMI) thrombus classification.
  • SII was calculated as platelet count × neutrophil count / lymphocyte count. NLR and PLR were also computed.

Main Results:

  • High NLR, PLR, SII, and low left ventricle ejection fraction (LVEF) were identified as independent predictors of high thrombus burden.
  • SII values above 812 demonstrated significant predictive power for high thrombus burden (AUC: 0.836).
  • The predictive performance of SII was superior to that of NLR (AUC: 0.818) and PLR (AUC: 0.780).

Conclusions:

  • The systemic immune-inflammation index (SII) is an independent predictor of high thrombus burden in STEMI patients.
  • SII exhibits superior predictive capacity for high thrombus burden compared to NLR and PLR in this population.
  • These findings suggest SII could be a valuable biomarker for risk stratification in STEMI patients.
Abstract

Keywords:
InflammationST-segment elevation myocardial infarctionneutrophil-lymphocyte ratioplatelet-lymphocyte ratiosystemic immune-inflammation indexthrombus burden

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