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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

497
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
372
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
581
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

221
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

260
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

1.9K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
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Updated: Oct 4, 2025

A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients
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A Retrospective Study on Endoscopic Surgery for the Treatment of Paravertebral Abscess in Spinal Tuberculosis Patients

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Intracranial and Spinal Tuberculosis: A Rare Entity.

Sara Rehman1, Anis U Rehman1, Muhammed A Naveed1

  • 1Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Cureus
|February 3, 2022
PubMed
Summary

Central nervous system tuberculosis presents diverse patterns and risks. This case highlights neurotuberculosis with intracranial and spinal lesions, meningitis, and spondylodiscitis in a sarcoidosis patient on corticosteroids, emphasizing early diagnosis for better outcomes.

Keywords:
cnspott's diseasespinetuberculomatuberculosis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Central nervous system (CNS) tuberculosis (TB) is a severe condition with high mortality and complication rates.
  • Corticosteroid use in patients with underlying conditions like sarcoidosis can increase susceptibility to opportunistic infections, including TB.

Observation:

  • A 36-year-old male with a history of sarcoidosis on corticosteroids presented with headache, fever, backache, lower limb weakness, and altered sensorium.
  • Imaging revealed intracranial and spinal tuberculomas, meningitis, and spondylodiscitis.
  • Cerebrospinal fluid (CSF) culture confirmed Mycobacterium tuberculosis.

Findings:

  • The patient was diagnosed with neurotuberculosis, encompassing meningitis, intracranial/spinal tuberculomas, and spondylodiscitis.
  • The clinical presentation was complicated by immunosuppression due to corticosteroid therapy for sarcoidosis.
  • Diagnostic confirmation relied on a combination of imaging findings and positive CSF culture for Mycobacterium tuberculosis.

Implications:

  • Early diagnosis of neurotuberculosis, especially in immunocompromised individuals, is crucial for effective treatment.
  • Integrated clinicopathological and imaging correlation aids in timely diagnosis and management.
  • Prompt treatment can prevent severe neurological sequelae and reduce mortality associated with CNS TB.