Related Experiment Video
Updated: Oct 4, 2025

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Use of platelet components: An observational audit at a tertiary care centre
Deepika Chenna1, Shamee Shastry1, Poornima Baliga1
1Department of Immunohematology and Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
Abstract:
Background Platelets should be transfused appropriately, based on the cause of thrombocytopenia. The practice and policies of transfusion vary among institutions and even among clinical practitioners, leading to inappropriate use of platelets, which might increase the risk of transfusion-related complications to recipients, and lead to a shortage of platelets. An audit of platelet components helps to determine the effectiveness and appropriateness of their use and in improving transfusion practices. We did an audit of the use of platelet transfusions at our centre. Methods We conducted a prospective concurrent audit of the platelet transfusion practices. The audit cycle had four steps: (i) defining the standards; (ii) data collection; (iii) comparison against the standards; and (iv) presenting them to clinicians for further improvement. Results Platelet components were used appropriately in 93.6% (2420/2586) of episodes. The platelet count was not done before transfusion in only 6.4% (165/2586) of episodes. The dose of platelets was given appropriately in 84.3% (2180) of episodes of transfusion. Indications for appropriate transfusion classified as pre-procedure, prophylactic and therapeutic transfusions were 11.3% (293), 66.1% (1450) and 13% (412), respectively. Medicine and medical oncology were the specialties with the highest level of appropriateness. Conclusion An audit of transfusion practices benefits transfusion services and clinicians in terms of judicious use of platelet components and better inventory management.
Related Concept Videos
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

