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Relationship between polymorphism rs2794521 in CRP gene and survival of depressive patients with chronic heart

G Opielak1, T Powrózek, A Skwarek-Dziekanowska

  • 1Department of Human Physiology, Medical University of Lublin, Lublin, Poland. opielak@gmail.com.

European Review for Medical and Pharmacological Sciences
|February 3, 2022
PubMed

Insights

The CC genotype of C-reactive protein (CRP) is more common in patients with depression and chronic heart failure (CHF). This genotype is linked to poorer health outcomes and increased mortality risk in these patients.

Area of Science:

  • Cardiovascular Medicine
  • Psychiatry
  • Genetics

Background:

  • Depression and chronic heart failure (CHF) often coexist, impacting patient prognosis.
  • The role of C-reactive protein (CRP) polymorphisms, specifically rs2794521, in patients with both conditions is not well-understood.

Purpose of the Study:

  • To investigate the association between the CRP rs2794521 polymorphism and the clinical profile and survival of patients with comorbid depression and CHF.
  • To determine if specific CRP genotypes influence depression occurrence and disease severity in CHF patients.

Main Methods:

  • A cohort of 103 patients with chronic heart failure (CHF) was analyzed for depression.
  • Patients' cardiac, laboratory, and nutritional parameters were compared based on their CRP genotypes (rs2794521).

Main Results:

  • The CC genotype of CRP was more prevalent in patients with depression (p=0.021).
  • CC genotype individuals exhibited higher CRP and TNF-α levels, more severe CHF (NYHA grade III-IV), and increased malnutrition (SGA).
  • The CC genotype was significantly associated with a higher risk of early mortality over 72 months (HR=4.46).

Conclusions:

  • The CC genotype of CRP is more frequent in CHF patients with depression.
  • This genotype is linked to a worse clinical profile, including increased inflammation and malnutrition.
  • The CRP CC genotype is an independent predictor of reduced survival in patients with comorbid depression and CHF.
Abstract

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