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Holt-Oram syndrome

A Skwarek-Dziekanowska1, A Wójtowicz-Ściślak, G Sobieszek

  • 1Department of Cardiology, 1st Military Clinical Hospital with the Outpatient Clinic, Lublin, Poland. anetask@gmail.com.

European Review for Medical and Pharmacological Sciences
|January 18, 2024
PubMed

Insights

Holt-Oram syndrome patients requiring pacemakers can benefit from His-bundle pacing. This technique offers physiological pacing, potentially preventing heart failure and maintaining cardiac function.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Devices

Background:

  • Holt-Oram syndrome (HOS) is a rare genetic disorder.
  • HOS involves upper limb abnormalities, congenital heart defects, and cardiac conduction issues.
  • Patients with HOS often require pacemakers due to conduction disturbances.

Observation:

  • A case report details a patient with HOS needing pacemaker implantation for bradycardia.
  • His-bundle pacing was employed to prevent future heart failure.
  • The implantation was successful, with the patient in good condition after one year.

Findings:

  • The patient maintained over 90% pacing.
  • Left ventricular ejection fraction (LVEF) remained stable at 60%.
  • This demonstrates the efficacy of His-bundle pacing in HOS.

Implications:

  • His-bundle pacing is a novel physiological pacing method.
  • This technique may prevent heart failure in HOS patients.
  • Further research is needed on optimal pacing strategies for HOS.
Abstract

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