Related Experiment Video

Updated: Oct 4, 2025

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
06:34

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability

Published on: April 28, 2022

5.1K

Serum Ferritin Threshold for Iron Deficiency Screening in One-Year-Old Children

Narmin Mukhtarova1, Barbara Ha2, Carol A Diamond3

  • 1School of Medicine and Public Health, and UnityPoint Health Meriter Hospital, University of Wisconsin, Madison, WI.

The Journal of Pediatrics
|February 3, 2022
PubMed

Insights

Universal iron deficiency anemia screening at 1 year is recommended. This study suggests combining hemoglobin and serum ferritin tests, raising the ferritin threshold for better diagnosis of iron deficiency in infants.

Area of Science:

  • Pediatrics
  • Hematology
  • Nutritional Science

Background:

  • The American Academy of Pediatrics recommends universal hemoglobin screening for iron deficiency anemia at the 1-year-old well-child visit.
  • Current guidelines use a hemoglobin threshold of <110 g/L for diagnosis.

Observation:

  • A retrospective study was conducted to evaluate screening methods for iron deficiency anemia.
  • The study analyzed data from 1-year-old children undergoing routine well-child visits.

Findings:

  • Combined hemoglobin and serum ferritin screening may offer improved detection of iron deficiency anemia.
  • Raising the diagnostic serum ferritin threshold to 24-25 μg/L is suggested for enhanced accuracy.

Implications:

  • These findings could lead to revised screening guidelines for iron deficiency anemia in infants.
  • Optimizing diagnostic thresholds can ensure timely and effective intervention for affected children.

Keywords:
anemiahemoglobinrestricted cubic spline regression

More Related Videos

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

959
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

4.9K

Related Concept Videos

The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.6K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
21
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
104