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Endogenous opiates and behavior: 2020.

Richard J Bodnar1

  • 1Department of Psychology and Neuropsychology Doctoral Sub-Program, Queens College, City University of New York, Flushing, NY, 11367, United States.

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|February 3, 2022
PubMed
Summary
This summary is machine-generated.

This review covers 2020 research on the endogenous opioid system, detailing how manipulating opioid peptides and receptors affects behavior. It examines roles in pain, addiction, stress, and various physiological functions.

Keywords:
AddictionDelta opioid receptorDynorphinsEndorphinsEnkephalinsKappa opioid receptorMu opioid receptorNociceptinOpioid overdoseTolerance and dependence

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The endogenous opioid system modulates numerous physiological and behavioral processes.
  • Annual reviews are crucial for synthesizing the rapidly evolving research in this field.

Purpose of the Study:

  • To provide a comprehensive overview of research published in 2020 on the endogenous opioid system.
  • To summarize studies investigating the behavioral effects of endogenous opioid system manipulation.

Main Methods:

  • Systematic review and synthesis of scientific literature published in 2020.
  • Categorization of research based on specific physiological and behavioral domains.

Main Results:

  • Extensive research explored molecular, pharmacological, and genetic manipulations of opioid peptides and receptors.
  • Opioid system involvement was detailed across diverse areas including pain, analgesia, addiction, stress, and neurological disorders.

Conclusions:

  • The endogenous opioid system remains a critical target for understanding and treating a wide range of conditions.
  • Continued research is vital for elucidating the complex roles of opioid peptides and receptors in health and disease.