Clinical pharmacologic implications in diuretic selection

Logical and comprehensive diuretic therapy is based on a sound knowledge of renal physiologic principles. Knowledge of the sites within the nephron at which the currently available diuretics work and their modes of action provide the clinician with a basis upon which to arrive at therapeutic decisions. True diuretic resistance is uncommon, but when it occurs, sequential nephron blockade can frequently reverse the refractoriness initially exhibited by the patient.