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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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The mTOR pathway or the...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...

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Related Experiment Video

Updated: Oct 4, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Long non-coding RNAs regulating multiple proliferative pathways in cancer cell.

Marco De Martino¹, Francesco Esposito¹, Pierlorenzo Pallante¹

¹Institute of Experimental Endocrinology and Oncology (IEOS) "G. Salvatore", National Research Council (CNR), Naples, Italy.

Translational Cancer Research

|February 4, 2022

Summary

This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate cell proliferation in cancer. This review details lncRNAs acting as oncogenes or tumor suppressors, offering insights for cancer treatment.

Keywords:

Long non-coding RNA (lncRNA)cancer cell proliferation

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Published on: December 13, 2018

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Last Updated: Oct 4, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Area of Science:

Molecular Biology
Genetics
Oncology

Background:

Long non-coding RNAs (lncRNAs) are a diverse group of RNA molecules.
Aberrant lncRNA expression is linked to various pathologies, particularly cancer.
lncRNAs play crucial roles in regulating cellular pathways, including cancer cell proliferation.

Purpose of the Study:

To review the role of specific lncRNAs in regulating cancer cell proliferation.
To categorize lncRNAs based on their function in proliferative pathways: tumor suppressor, oncogenic, or transcriptionally-driven.
To highlight the intricate molecular network formed by lncRNA interactions in cancer.

Main Methods:

Literature review focusing on lncRNAs involved in cell proliferation.
Classification of lncRNAs based on their oncogenic or tumor-suppressive functions.
Detailed characterization of selected lncRNAs, including oncogenes (e.g., H19, HOTAIR) and tumor suppressors (e.g., MEG3, lincRNA-p21).

Main Results:

Identified lncRNAs that positively or negatively modulate cell growth.
Detailed specific lncRNAs acting as oncogenes (H19, linc-ROR, MALAT1, HULC, HOTAIR, ANRIL).
Detailed specific lncRNAs acting as tumor suppressors (MEG3, lincRNA-p21) and dual roles (UCA1, TUG1).

Conclusions:

lncRNAs form a complex regulatory network controlling cell proliferation in cancer.
Understanding these lncRNA-target interactions is vital for developing novel cancer therapies.
Targeting lncRNAs holds potential for treating molecular diseases like cancer.