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The malignancy among gastric submucosal tumor
1Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Translational Cancer Research
|February 4, 2022
Summary
Most gastric submucosal tumors (SMTs) are presumed benign, but malignancy potential exists. Further investigation and intervention for gastric SMTs are crucial for patient outcomes.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Gastrointestinal endoscopy and radiological examinations often fail to definitively diagnose submucosal tumors (SMTs).
- The clinical management, including intervention necessity and timing, for non-Gastrointestinal Stromal Tumor (GIST) gastric SMTs is frequently overlooked.
- The true malignancy potential of various gastric SMTs remains uncertain.
Purpose of the Study:
- To investigate and summarize the malignancy potential of diverse gastric submucosal tumors (SMTs).
- To highlight the importance of considering malignancy in gastric SMTs beyond GISTs.
Main Methods:
- Comprehensive literature review and analysis of reported cases of gastric SMTs.
- Inclusion of various SMT types: heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma, granular cell tumor (GCT), lipoma, hemangiopericytoma, lymphangioma, and neurofibroma.
Main Results:
- Malignant cases were identified in literature for heterotopic pancreas, leiomyoma, schwannoma, glomus tumor, hemangioendothelioma, and granular cell tumor (GCT).
- This indicates that even tumors typically considered benign can exhibit malignant potential.
Conclusions:
- While most gastric SMTs are benign, the possibility of malignancy necessitates careful consideration.
- Active intervention and long-term follow-up are recommended for gastric SMTs to address potential malignancy.
