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MTA1 is an indicator of prognosis in Chinese patients with lung adenocarcinoma
1Department of Gerontology, The First People's Hospital of Changzhou, Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Background:
The predictive role of metastatic tumor antigen 1 (MTA1) expression in lung cancer (LC) is still uncertain. This meta-analysis was performed to clarify the relationship of MTA1 protein expression with the prognosis of LC.
Methods:
The PubMed and CNKI databases were searched for clinical studies demonstrating the expression of MTA1 in LC for further review.
Results:
A total of ten studies comprising 982 patients were included in the meta-analysis according to the predefined selection criteria. Our results indicated that MTA1 overexpression had a significant impact on progression-free survival (PFS) (HR 2.16; 95% CI, 1.62-2.89) and OS (HR 2.38; 95% CI, 1.78-3.19). Heterogeneity was observed (I2=34.6%). When the analyses were restricted to adenocarcinoma cases, high expression of MTA1 also predicted poor prognosis (HR 2.14; 95% CI, 1.48-3.08). However, no statistically significant heterogeneity was observed among the studies (I2=4.1%).
Conclusions:
A high level of MTA1 expression predicts poor survival in Chinese patients with lung adenocarcinoma.
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