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Related Experiment Video

Updated: Jun 19, 2026

Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava
06:59

Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava

Published on: January 13, 2023

Idiopathic hypovolemia.

F M Fouad, L Tadena-Thome, E L Bravo

    Annals of Internal Medicine
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Idiopathic hypovolemia, a condition of low blood volume, causes orthostatic intolerance. Volume expansion therapies effectively treat symptoms and improve heart rate response in affected patients.

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    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology
    • Nephrology

    Background:

    • Orthostatic intolerance (OI) affects numerous individuals, often without a clear cause.
    • Reduced blood volume (hypovolemia) can significantly contribute to OI symptoms.

    Purpose of the Study:

    • To characterize a syndrome of idiopathic hypovolemia presenting with OI.
    • To investigate the efficacy of volume expansion in managing this condition.

    Main Methods:

    • Studied eleven patients with unexplained hypovolemia and OI.
    • Performed diagnostic tests to exclude other causes of hypovolemia.
    • Assessed hemodynamic responses to head-up tilt before and after volume expansion therapies.

    Main Results:

    • Patients exhibited marked idiopathic hypovolemia and abnormal heart rate responses to tilt.
    • Acute plasma volume expansion with albumin improved symptoms and tilt response.
    • Long-term volume expansion with florinef and salt normalized tilt tests in most patients.

    Conclusions:

    • Identified a distinct syndrome of idiopathic hypovolemia causing OI, labile hypertension, and tilt intolerance.
    • Volume expansion is a promising therapeutic strategy for this condition.